John G Lewis Selected Research

Calcium Gluconate (CBG)

12/2020	Pyrexia and acidosis act independently of neutrophil elastase reactive center loop cleavage to effect cortisol release from corticosteroid-binding globulin.
8/2020	High binding site occupancy of corticosteroid-binding globulin by progesterone increases fetal free cortisol concentrations.
1/2019	Neutrophil elastase-cleaved corticosteroid-binding globulin is absent in human plasma.
1/2019	Total and high-affinity corticosteroid-binding globulin depletion in septic shock is associated with mortality.
3/2017	Differential Effects of Estrogen on Corticosteroid-Binding Globulin Forms Suggests Reduced Cleavage in Pregnancy.
1/2017	Corticosteroid-binding globulin: acute and chronic inflammation.
1/2017	Corticosteroid-binding globulin cleavage may be pathogen-dependent in bloodstream infection.
1/2017	Monoclonal antibodies to the reactive centre loop (RCL) of human corticosteroid-binding globulin (CBG) can protect against proteolytic cleavage.
1/2016	Reduced corticosteroid-binding globulin cleavage in active rheumatoid arthritis.
5/2015	The half-lives of intact and elastase cleaved human corticosteroid-binding globulin (CBG) are identical in the rabbit.

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John G Lewis Research Topics

Disease

15	Inflammation (Inflammations) 12/2020 - 06/2007
8	Sepsis (Septicemia) 12/2020 - 01/2009
4	Septic Shock (Toxic Shock Syndrome) 01/2019 - 01/2009
3	Adrenal Insufficiency (Adrenal Gland Hypofunction) 11/2014 - 03/2009
3	Insulin Resistance 09/2008 - 07/2007
2	Infections 12/2021 - 01/2017
2	Fever (Fevers) 12/2020 - 04/2016
2	Corticosteroid-Binding Globulin Deficiency 01/2009 - 09/2005
1	Aspergillosis 05/2022
1	Acidosis 12/2020
1	Respiratory Tract Infections (Respiratory Tract Infection) 07/2020
1	Critical Illness (Critically Ill) 01/2019
1	Lymphoma (Lymphomas) 01/2018
1	Breast Neoplasms (Breast Cancer) 01/2018
1	Neoplasms (Cancer) 01/2018
1	Puerperal Infection (Puerperal Infections) 03/2017
1	Neutropenia 01/2017
1	Emphysema 01/2016
1	Premature Obstetric Labor (Premature Labor) 01/2016
1	Rheumatoid Arthritis 01/2016
1	Obesity 01/2016
1	Birth Weight (Birth Weights) 01/2016
1	Type 2 Diabetes Mellitus (MODY) 04/2012
1	Wounds and Injuries (Trauma) 01/2012
1	Hip Fractures (Intertrochanteric Fractures) 01/2012
1	Hypotension (Low Blood Pressure) 10/2011
1	Chronic Pain 10/2011
1	Fatigue 10/2011
1	Pain (Aches) 10/2011
1	Addison Disease (Addison's Disease) 03/2009
1	Cushing Syndrome 01/2009
1	Overweight 09/2008
1	Pre-Eclampsia (Preeclampsia) 06/2007
1	Pregnancy-Induced Hypertension (Hypertension, Pregnancy Induced) 06/2007
1	Fetal Growth Retardation (Intrauterine Growth Retardation) 06/2007
1	Hepatocellular Carcinoma (Hepatoma) 11/2006
1	Congenital Adrenal Hyperplasia (Hyperplasia, Congenital Adrenal) 08/2006
1	Pituitary ACTH Hypersecretion 08/2006
1	Hypopituitarism (Sheehan's Syndrome) 05/2006

Drug/Important Bio-Agent (IBA)

25	Hydrocortisone (Cortisol)FDA LinkGeneric 12/2020 - 09/2005
17	Calcium Gluconate (CBG)IBA 12/2020 - 09/2005
8	TranscortinIBA 12/2020 - 06/2007
4	Pancreatic Elastase (Elastase)IBA 05/2014 - 11/2011
3	Monoclonal AntibodiesIBA 05/2022 - 01/2018
3	Leukocyte Elastase (Neutrophil Elastase)IBA 12/2020 - 05/2015
3	AlbuminsIBA 01/2019 - 01/2009
3	Retinol-Binding Proteins (Retinoid Binding Proteins)IBA 09/2008 - 07/2007
2	Vitamin D-Binding ProteinIBA 07/2020 - 09/2018
2	AntibodiesIBA 01/2018 - 01/2017
2	Progesterone FDA LinkGeneric 03/2017 - 08/2006
2	Adrenocorticotropic Hormone (ACTH)FDA Link 01/2016 - 05/2006
2	GlucocorticoidsIBA 01/2016 - 11/2014
2	Glucose (Dextrose)FDA LinkGeneric 09/2008 - 04/2008
2	Insulin (Novolin)FDA Link 09/2008 - 04/2008
1	AntigensIBA 12/2021
1	SteroidsIBA 12/2020
1	EnzymesIBA 08/2020
1	Vitamin D FDA LinkGeneric 07/2020
1	hydroxide ionIBA 07/2020
1	Cholecalciferol (Vitamin D3)FDA Link 07/2020
1	25-hydroxyvitamin DIBA 07/2020
1	Peptides (Polypeptides)IBA 09/2018
1	Trastuzumab (Herceptin)FDA Link 01/2018
1	Rituximab (Mabthera)FDA Link 01/2018
1	GoldIBA 01/2018
1	MyoglobinIBA 05/2017
1	NeopterinIBA 05/2017
1	Proteins (Proteins, Gene)FDA Link 04/2016
1	Peptide Hydrolases (Proteases)FDA Link 01/2016
1	Carrier Proteins (Binding Protein)IBA 01/2016
1	Hormones (Hormone)IBA 01/2016
1	Betaine (C.B.B.)FDA Link 01/2012
1	Carnitine (L-Carnitine)FDA LinkGeneric 01/2012
1	C-Reactive ProteinIBA 01/2012
1	Thyroxine (Levothyroxine)FDA LinkGeneric 03/2009
1	Cosyntropin (Cortrosyn)FDA LinkGeneric 01/2009
1	LipidsIBA 04/2008
1	Estradiol (Delestrogen)FDA LinkGeneric 08/2006
1	Metyrapone FDA Link 05/2006
1	Cortodoxone (11 Deoxycortisol)IBA 05/2006

Therapy/Procedure

1	Critical Care (Surgical Intensive Care) 09/2018